841Estimation of Undiagnosed Neuroinfectious Deaths with the Epidemiologic Pattern of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri
نویسندگان
چکیده
Epidemiologic Pattern of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri Almea Matanock, MD; Jason Mehal, MPH; Lindy Liu, MPH; Dianna M. Blau, DVM, PhD; Jennifer Cope, MD, MPH; Waterborne Disease Prevention Branch, Centers for Disease Control and Prevention, Atlanta, GA; Centers for Disease Control and Prevention, Atlanta, GA; Infectious Disease Pathology Laboratory, Centers for Disease Control and Prevention, Atlanta, GA
منابع مشابه
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States1
Primary amebic meningoencephalitis is an acute, rare, typically fatal disease. We used epidemiologic risk factors and multiple cause-of-death mortality data to estimate the number of deaths that fit the typical pattern for primary amebic meningoencephalitis; we estimated an annual average of 16 deaths (8 male, 8 female) in the United States.
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Infections caused by free-living amebae (FLA) are severe and life-threatening. These infections include primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species. Although several drugs have in vitro activity against FLA, mortality from these infections remains>90% despite treatment with ...
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Primary amebic meningoencephalitis (PAM) is a rare but nearly always fatal disease caused by infection with Naegleria fowleri, a thermophilic, free-living ameba found in freshwater environments. Infection results from water containing N. fowleri entering the nose, followed by migration of the amebae to the brain via the olfactory nerve. In 2007, six cases of PAM in the United States were report...
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Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient's survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosi...
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